Quantum cryptography protocols robust against photon number splitting attacks for weak laser pulses implementations

We introduce a new class of quantum quantum key distribution protocols, tailored to be robust against photon number splitting (PNS) attacks. We study one of these protocols, which differs from the BB84 only in the classical sifting procedure. This protocol is provably better than BB84 against PNS attacks at zero error.Comment: 4 pages, 2 figure

Highly nonclassical photon statistics in parametric down conversion

We use photon counters to obtain the joint photon counting statistics from twin-beam non-degenerate parametric down conversion, and we demonstrate directly, and with no auxiliary assumptions, that these twin beams are nonclassical

Tight focusing of plane waves from micro-fabricated spherical mirrors

We derive a formula for the light field of a monochromatic plane wave that is truncated and reflected by a spherical mirror. Our formula is valid even for deep mirrors, where the aperture radius approaches the radius of curvature. We apply this result to micro-fabricated mirrors whose size scales are in the range of tens to hundreds of wavelengths, and show that sub-wavelength spot sizes can be achieved. This opens up the possibility of scalable arrays of tightly focused optical dipole traps without the need for high-performance optical systems.Comment: 8 pages, 5 color figures, 1 .sty file; changes made in response to referee comments; published in Optics Expres

Experimental demonstration of phase measurement precision beating standard quantum limit by projection measurement

We propose and demonstrate experimentally a projection scheme to measure the quantum phase with a precision beating the standard quantum limit. The initial input state is a twin Fock state $|N,N>$ proposed by Holland and Burnett [Phys. Rev. Lett. {\bf 71}, 1355 (1993)] but the phase information is extracted by a quantum state projection measurement. The phase precision is about $1.4/N$ for large photon number $N$, which approaches the Heisenberg limit of 1/N. Experimentally, we employ a four-photon state from type-II parametric down-conversion and achieve a phase uncertainty of $0.291\pm 0.001$ beating the standard quantum limit of $1/\sqrt{N} = 1/2$ for four photons.Comment: 5 figure

Cell-to-cell variability of alternative RNA splicing

The role of mRNA processing in gene expression variability is poorly characterized. This study investigates the extent of cell-to-cell variability of alternative RNA splicing in mammalian cells using single-molecule imaging of CAPRIN1 and MKNK2 splice isoforms

Crosstalk calibration of multi-pixel photon counters using coherent states

We present a novel method of calibration of crosstalk probability for multi-pixel photon counters (MPPCs) based on the measurement of the normalized second-order intensity correlation function of coherent light. The method was tested for several MPPCs, and was shown to be advantageous over the traditional calibration method based on the measurements of the dark noise statistics. The method can be applied without the need of modification for different kinds of spatially resolved single photon detectors.Comment: 8 pages, 3 figures, 2 table

Temporal trends and lesion sets for persistent atrial fibrillation ablation: a meta-analysis with trial sequential analysis and meta-regression

BACKGROUND: Ablation for persistent atrial fibrillation (PsAF) has been performed for over 20 years, although success rates have remained modest. Several adjunctive lesion sets have been studied but none have become standard of practice. We sought to describe how the efficacy of ablation for PsAF has evolved in this time period with a focus on the effect of adjunctive ablation strategies. METHODS: Databases were searched for prospective studies of PsAF ablation. We performed meta-regression and trial sequential analysis. RESULTS: A total of 99 studies (15 424 patients) were included. Ablation for PsAF achieved the primary outcome (freedom of atrial fibrillation/atrial tachycardia rate at 12 months follow-up) in 48.2% (5% CI, 44.0-52.3). Meta-regression showed freedom from atrial arrhythmia at 12 months has improved over time, while procedure time and fluoroscopy time have significantly reduced. Through the use of cumulative meta-analyses and trial sequential analysis, we show that some ablation strategies may initially seem promising, but after several randomized controlled trials may be found to be ineffective. Trial sequential analysis showed that complex fractionated atrial electrogram ablation is ineffective and further study of this treatment would be futile, while posterior wall isolation currently does not have sufficient evidence for routine use in PsAF ablation. CONCLUSIONS: Overall success rates from PsAF ablation and procedure/fluoroscopy times have improved over time. However, no adjunctive lesion set, in addition to pulmonary vein isolation, has been conclusively demonstrated to be beneficial. Through the use of trial sequential analysis, we highlight the importance of adequately powered randomized controlled trials, to avoid reaching premature conclusions, before widespread adoption of novel therapies

Superconducting nanowire photon number resolving detector at telecom wavelength

The optical-to-electrical conversion, which is the basis of optical detectors, can be linear or nonlinear. When high sensitivities are needed single-photon detectors (SPDs) are used, which operate in a strongly nonlinear mode, their response being independent of the photon number. Nevertheless, photon-number resolving (PNR) detectors are needed, particularly in quantum optics, where n-photon states are routinely produced. In quantum communication, the PNR functionality is key to many protocols for establishing, swapping and measuring entanglement, and can be used to detect photon-number-splitting attacks. A linear detector with single-photon sensitivity can also be used for measuring a temporal waveform at extremely low light levels, e.g. in long-distance optical communications, fluorescence spectroscopy, optical time-domain reflectometry. We demonstrate here a PNR detector based on parallel superconducting nanowires and capable of counting up to 4 photons at telecommunication wavelengths, with ultralow dark count rate and high counting frequency